Health
| In Dr. Terry Grossman's Program for Optimal Wellness (POW), supplements and vitamins are a big component of the plan. In the list presented in this article, Grossman's top ten drugs and nutrients for life extension are outlined. |
For many years, Dr. Terry Grossman has explored and promoted anti-aging medicine. He has developed numerous cutting-edge protocols for measuring and modifying biological age and promoting longevity. Grossman has studied nutritional and anti-aging medicine in 1994 and in 1995 opened Frontier Medical Institute (now Grossman Wellness Center) in Denver, which quickly grew into one of the largest complementary medical centers in the country.
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| Dr. Terry Grossman |
and Transcend: Nine Steps to Living Well Forever
with Ray Kurzweil that examine anti-aging methods and technologies. Grossman and Kurzweil have proposed that there are three bridges to the future of anti aging medicine: the medicine of today; biotechnology and; nanotechnology.By 2025, nanotechnology medicine will largely impact our lives according to Grossman, but until this develops, what can a person do in 'Bridge One Medicine'?
Grossman promotes the following top ten drugs and nutrients for anti-aging as part of his Program for Optimal Wellness (POW):
(Please be aware that the information below is instructional only, and should not be viewed as medical advice. Your are advised to consult with your doctor before taking any of these drugs and supplements.)
1. Metformin
Metformin is first-line drug of choice for the treatment of Type 2 diabetes, in particular, in overweight and obese people and those with normal kidney function. Essentially the drug prevents an excessive production of insulin resulting from too much glucose in the bloodstream.
Its use in gestational diabetes has been limited by safety concerns. It is also used in the treatment of polycystic ovary syndrome, and has been investigated for other diseases where insulin resistance may be an important factor. Metformin works by suppressing glucose production by the liver.
Metformin is the only antidiabetic drug that has been conclusively shown to prevent the cardiovascular complications of diabetes. It helps reduce LDL cholesterol and triglyceride levels, and is not associated with weight gain. As of 2010, Metformin is one of only two oral antidiabetics in the World Health Organization Model List of Essential Medicines.
Grossman and others argue that Metformin also has pronounced effects on aging and cancer. The drug has been found to reduce the production of inflammatory cytokines that normally activate the immune system, but if overproduced can lead to pathological inflammation, a condition that both damages tissues in aging and favors tumor growth.
In studies, Metformin use extended lifespan of mice by 37.8%.
Cancer feeds mainly on glucose, so in a glucose-rich environment it is more likely to grow. This correlates with a higher percentage of cancer in Type 2 diabetes patients. Cutting the glucose levels in the body with drugs like Metformin may therefore reduce the risk of developing certain cancers.
The benefits of the drug mean that Grossman recommends and takes Metformin as a preventative, anti-aging medication, even though he does not suffer from Type 2 diabetes.
Its use in gestational diabetes has been limited by safety concerns. It is also used in the treatment of polycystic ovary syndrome, and has been investigated for other diseases where insulin resistance may be an important factor. Metformin works by suppressing glucose production by the liver.
Grossman and others argue that Metformin also has pronounced effects on aging and cancer. The drug has been found to reduce the production of inflammatory cytokines that normally activate the immune system, but if overproduced can lead to pathological inflammation, a condition that both damages tissues in aging and favors tumor growth.
In studies, Metformin use extended lifespan of mice by 37.8%.
Cancer feeds mainly on glucose, so in a glucose-rich environment it is more likely to grow. This correlates with a higher percentage of cancer in Type 2 diabetes patients. Cutting the glucose levels in the body with drugs like Metformin may therefore reduce the risk of developing certain cancers.
The benefits of the drug mean that Grossman recommends and takes Metformin as a preventative, anti-aging medication, even though he does not suffer from Type 2 diabetes.
2. Low Dose Statins
Statin drugs are commonly prescribed now to prevent cardiac disease. Statins are drugs which lower the level of cholesterol in the blood. There are different types of statins, but they all work in the same way.With heart disease being the number one killer, defending against this may help increase lifespan.
There have been some associated side-effects on kidneys from statin use, however new studies reveal the risk to be low.
3. Aspirin
Acetylsalicyclic acid (ASA), commonly known as aspirin has long been thought to reduce cancer and cardiovascular death risk. Aspirin should be considered for men 45-80, women 55-80, especially if there is a family history of heart attack or stroke. To be used effectively it needs to be taken everyday.
You should take a daily aspirin only if your doctor advises you to do so. If you have had a heart attack or stroke, your doctor will likely recommend you take a daily aspirin unless you have a serious allergy or history of bleeding. If you have a high risk of having a first heart attack, your doctor might recommend aspirin after weighing the risks and benefits.
4. Tadalafil
Better known as the trade-name, Cialis is primarily prescribed for erectile disfunction but Grossman states it has anti-aging properties as well. Tadalafil, acts by inhibiting enzymes in the body that constrict blood flow.
Little is known of Tadalafil's anti-aging properties at this time.
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5. Carnosine
Carnosine is an amino acid compound found primarily in red meat. A typical red meat meal may provide 250 mg of carnosine, but this is quickly degraded in the body by the carnosinase enzyme. What this means is that even if a person relied on red meat for their carnosine, it would not last long enough in the body to provide sustained protective effects.Supplementation with carnosine overwhelms the carnosinase enzyme, thus enabling one to maintain consistent blood levels of this critical nutrient.
Carnosine has a number of antioxidant properties that may be beneficial. Carnosine has been proven to scavenge reactive oxygen species (ROS) as well as alpha-beta unsaturated aldehydes formed from peroxidation of cell membrane fatty acids during oxidative stress.
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| Image Source: Life Extension |
Dr. Sergey Stvolinsky, a anti-aging scientist at the Russian Academy, has studied carnosine for years. In 2010 he published some surprising results in the journal Rejuvenation Research about carnosine’s effect on fruit flies.
Fruit flies are incredibly useful experimental animals, particularly for genetic and aging research, because of their very short life spans and rapid reproductive rates. Stvolinsky and his research team found that adding a tiny amount of carnosine to the flies’ food supply produced an immediate 20% increase in the average life span of male flies. Alone, carnosine had little effect on female flies’ life span, but when combined with a water-soluble form of vitamin E, female flies experienced a 36% increase in longevity as well.
Fruit flies are incredibly useful experimental animals, particularly for genetic and aging research, because of their very short life spans and rapid reproductive rates. Stvolinsky and his research team found that adding a tiny amount of carnosine to the flies’ food supply produced an immediate 20% increase in the average life span of male flies. Alone, carnosine had little effect on female flies’ life span, but when combined with a water-soluble form of vitamin E, female flies experienced a 36% increase in longevity as well.
6. Vitamin C
For years widespread public knowledge about the efficacy of Vitamin C has abounded. It all started with Dr. Linus Pauling, a two time Nobel Prize winning laureate. He himself started taking high doses of vitamin C in 1965. Pauling died in 1994 at the age of 93. Pauling believed that his death was delayed for 20 years because of his vitamin C intake, that went as high as 18,000 milligrams per day in later years. In his work on vitamin C, Dr. Pauling was clear that he believes that people can have an extra 12-18 years of life if one takes 3,200 to 12,000 milligrams of vitamin C per day (equivalent to 45-75 REDs). Corroborating his assertions in a study of 11,000 Americans where he postulate that intake of 300 mg of Vitamin C per day (equivalent to 5 servings of fruits and vegetables per day) adds up to 6 years to a man's life and 2 years to a woman's life. Likewise, cardiovascular disease in this group declined by significantly.
Vitamin C is a water-soluble antioxidant. Human beings are one of the few animals that cannot produce this vitamin on their own and therefore must get it from external source. Fortunately, it is found abundantly in fruits and vegetables such as citrus fruits, potatoes, papaya, tomato, and brussels sprouts. As a supplement it may be viewed as insurance against the increased demands of aging.
Vitamin C is a water-soluble antioxidant. Human beings are one of the few animals that cannot produce this vitamin on their own and therefore must get it from external source. Fortunately, it is found abundantly in fruits and vegetables such as citrus fruits, potatoes, papaya, tomato, and brussels sprouts. As a supplement it may be viewed as insurance against the increased demands of aging.
Vitamin C also comes in a fat-soluble form called ascorbyl palmitate. Once absorbed, ascorbyl palmitate has been shown in Dr. Pauling's studies to fortify the micro-capillary wall of blood vessels that often deteriorate due to the aging process. Taken In conjunction with the amino acids L-lysine and L-proline, Dr. Pauling's studies show substantial reduction in atheroclerosis plague in his subjects on this program.
7. Vitamin D
Advocacy of Vitamin D has increased over the last few years as it has been found in some studies to reduce aging, and preventing heart disease and cancer. It has also been linked to multiple sclerosis and juvenile diabetes. It's one of the best ways of reducing infection rates. According to Dr. Mehmet Oz, "It's got a ton of things that it does for you to make your immune system function the way you want it to function."It was only recently discovered that the Vitamin D precursor, D3 is in many more tissues than bone, and skin is one of them. Vitamin D metabolism in the epidermis begins with 7- dehydrocholesterol, which produces both cholesterol and previtamin D3. This generates calcitriol when the skin is exposed to UV. Calcitriol is jolly useful with antimicrobial activity (ever noticed how acne clears up in the sun), prevention of several skin deseases, protection from UV damage, and protection of the hair follicle.
8. DHEA
DHEA (Dehydroepiandrosterone) is a hormone that is naturally made by the human body. It can be made in the laboratory from chemicals found in wild yam and soy. However, the human body cannot make DHEA from these chemicals, so simply eating wild yam or soy will not increase DHEA levels.DHEA is used for slowing or reversing aging, improving thinking skills in older people, and slowing the progress of Alzheimer’s disease.
Natural DHEA levels in the body begin to decrease after age 30, and are reported to be low in some people with anorexia, end-stage kidney disease, type 2 diabetes (non-insulin dependent diabetes), AIDS, adrenal insufficiency, and in the critically ill. DHEA levels may also be depleted by a number of drugs, including insulin, corticosteroids, opiates, and danazol.
No studies on the long-term effects of DHEA have been conducted. DHEA can cause higher than normal levels of androgens and estrogens in the body, and theoretically may increase the risk of prostate, breast, ovarian, and other hormone-sensitive cancers.
9. Coenzyme Q10
Coenzyme Q10 (CoQ10) is a substance that’s found naturally in the body and helps convert food into energy. It is found in almost every cell in the body, and it is a powerful antioxidant.
Antioxidants fight damaging particles in the body known as free radicals, which damage cell membranes, tamper with DNA, and even cause cell death. Scientists believe free radicals contribute to the aging process, as well as a number of health problems, including heart disease and cancer. Antioxidants, such as CoQ10, can neutralize free radicals and may reduce or even help prevent some of the damage they cause.
Some researchers believe that CoQ10 may help with heart-related conditions, because it can improve energy production in cells, prevent blood clot formation, and act as an antioxidant.
10. EPA/DHA
EPA/DHA is an essential fatty acid which stands for docosahexaenoic acid and eicosapentaenoic acid. This essential fatty acid is an Omega 3 fat, which is found in cold water fish. EPA DHA are highly unsaturated fat because of they contain 6 and 5 double bond s on their long structural chain. These polyunsaturated fats play a very important role with the function of our bodies.EPA and DHA are vital nutrients and may be taken to maintain healthy function of the following: Brain and Retina- DHA is a building block of tissue in the brain and retina of the eye. It helps with forming neural transmitters, such as phosphatidylserine, which is important for brain function. DHA is found in the retina of the eye and taking DHA may be necessary for maintaining healthy levels of DHA for normal eye function.
Are there any other nutritional supplements or vitamins that you take for life extension or overall health reasons?
SOURCE A4MVideo
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