Decreasing Astrocyte Brain-Cell Receptors Found to Boost Memory in Mice

 Neuroscience  

Researchers  have uncovered a new memory regulator in the brain involving adenosine receptors, which may offer a potential treatment to improve memory in Alzheimer’s disease.

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cientists from the Gladstone Institutes have shown that decreasing the number of A2A adenosine receptors in a particular type of brain cells called astrocytes improved memory in healthy mice. What’s more, reducing receptor levels also prevented memory impairments in a mouse model of Alzheimer’s disease.

The study has been published in Nature Neuroscience, the findings suggest that astrocytes—star-shaped cells that are abundant in the brain and support neuronal function—are important regulators of information storage, and their dysfunction might lead to memory decline in disease.

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“Our findings have provided us not only with a new perspective on the role of astrocytes in cognition, but also with an exciting drug target to enhance memory and maybe even stave off memory decline in Alzheimer’s disease,” says senior author Lennart Mucke, MD, director of the Gladstone Institute of Neurological Disease and professor of neurology and neuroscience at the University of California, San Francisco. “Next, we will explore the therapeutic implications of our discovery by repurposing available drugs that block these adenosine receptors and are well tolerated in humans.”

"Our findings have provided us not only with a new perspective on the role of astrocytes in cognition, but also with an exciting drug target to enhance memory and maybe even stave off memory decline in Alzheimer’s disease."

The researchers focused on astrocytes after their initial finding that patients with Alzheimer’s disease have unusually high numbers of adenosine receptors in these cells. However, whether this increase was linked to cognitive ability was unknown. solve this mystery, the scientists generated mice with normal or reduced levels of A2A receptors in astrocytes and compared them on tests of learning and memory.

While the mice showed no differences in learning, those that had fewer adenosine receptors performed better on tests of long-term memory. Moreover, reducing the number of receptors improved memory in older mice that often have memory deficits.

Taking this one step further, the researchers performed the same experiments in a mouse model of Alzheimer’s disease to see if these astrocytic adenosine receptors were also involved in memory loss associated with the disease. Once again, decreasing the number of receptors improved memory, even in the presence of amyloid plaques characteristic of Alzheimer’s.

The scientists say that they were surprised the effect of manipulating astrocytes was restricted to long-term memory with no changes occurring in learning or general behaviors. “Given the many roles of astrocytes in the brain, one might expect a global disruption of brain function,” says lead author Anna Orr, PhD, a staff scientist at Gladstone. “Instead, we see a very specific effect on memory retention.”

SOURCE  Gladstone Institutes

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