Anti-Aging
New research in Canada has identified plant extracts containing the six best groups of age-defying molecules ever observed before. The effects were observed in yeast, but they may produce very similar effects in humans as well.
Gaining the capability to slow down and possibly reverse the ageing process will be the most important medical discovery this century, and research is well on its way to extending the gains made in life expectancy in the last 100 years.
Now, a new study published in the journal Oncotarget by researchers from Concordia University and the Quebec-based biotech company Idunn Technologies may have found an important factor in the anti-aging quest. They have pinpointed plant extracts containing the six best groups of age-defying molecules ever observed before.
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In the study, the research team combed through Idunn Technologies’ extensive biological library, conducting more than 10,000 trials to screen for plant extracts that would increase the chronological lifespan of yeast.Yeast is frequently used in aging studies as the progresses unfold in similar manner for both yeast and humans. For many researchers, it is the preferred model organism for understanding how the anti-ageing process takes place.
"In total, we found six new groups of molecules that decelerate the chronological ageing of yeast."
“In total, we found six new groups of molecules that decelerate the chronological ageing of yeast,” says Vladimir Titorenko, the study’s senior author and a professor in the Department of Biology at Concordia. He carried out the study with a group of Concordia students and Éric Simard, the founder of Idunn Technologies, a company named after the goddess of rejuvenation in Norse mythology.This study has important implications not only for slowing the ageing process, but also for preventing certain diseases associated with ageing, including cancer.
“Rather than focus on curing the individual disease, interventions on the molecular processes of ageing can simultaneously delay the onset and progression of most age-related disorders,” says Simard, who notes that these new molecules will soon be available in commercial products.
“This kind of intervention is predicted to have a much larger effect on healthy ageing and life expectancy than can be attained by treating individual diseases."
“These results also provide new insights into mechanisms through which chemicals extracted from certain plants can slow biological ageing,” says Titorenko.
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| Does Willow bark hold a key to unlocking anti-aging treatments? |
An extract of willow bark has shown to be one of the most potent longevity-extending pharmacological interventions yet described in scientific literature.
The willow bark extract increased the average chronological lifespan of yeast by 475 percent and the maximum chronological lifespan by 369 percent.
Willow bark
was commonly used during the time of Hippocrates, when people were advised to chew on it to relieve pain and fever. The study showed that it increases the average and maximum chronological lifespan of yeast by 475 per cent and 369 per cent, respectively. This represents a much greater effect than rapamycin and metformin, the two best drugs known for their anti-ageing effects.“These six extracts have been recognized as non-toxic by Health Canada, and already exhibit recognized health benefits in humans,” says Simard.
“But first, more research must be done. That’s why Idunn Technologies is collaborating with four other universities for six research programs, to go beyond yeast, and work with an animal model of ageing, as well as two cancer models.”
Research Abstract:
We discovered six plant extracts that increase yeast chronological lifespan to a significantly greater extent than any of the presently known longevity-extending chemical compounds. One of these extracts is the most potent longevity-extending pharmacological intervention yet described. We show that each of the six plant extracts is a geroprotector which delays the onset and decreases the rate of yeast chronological aging by eliciting a hormetic stress response. We also show that each of these extracts has different effects on cellular processes that define longevity in organisms across phyla. These effects include the following: 1) increased mitochondrial respiration and membrane potential; 2) augmented or reduced concentrations of reactive oxygen species; 3) decreased oxidative damage to cellular proteins, membrane lipids, and mitochondrial and nuclear genomes; 4) enhanced cell resistance to oxidative and thermal stresses; and 5) accelerated degradation of neutral lipids deposited in lipid droplets. Our findings provide new insights into mechanisms through which chemicals extracted from certain plants can slow biological aging.
SOURCE Concordia University
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