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Is ageing a disease? Can it be cured? Can death be pushed back? Will you live to 1000 years? Aubrey de Grey, Chief Science Officer, SENS Research Foundation divulges the truth behind longevity and the ensuing risks.
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Showing posts with label SENS Foundation. Show all posts
Showing posts with label SENS Foundation. Show all posts
Tuesday, May 31, 2016
Monday, May 2, 2016
Anti-Aging
According to Aubrey de Grey old age and sickness, a disease that can be combated. He believes that like the myth of Tithonus, scientists today are too focused on the diseases of aging and not aging itself.
English author and biomedical gerontologist Aubrey de Grey is interviewed by Dutch journalist and philosopher Bas Heijne. De Grey is the founder of SENS Research Foundation, an institute that researches ways to rejuvenate the human body and stop aging. According to him, aging is a disease. In this video, Heijne and De Grey talk about his vision, technologies that make prevention of aging possible and the meaning of death.
According to de Grey aging is not a necessary part of our life but a medical problem that can be solved. Before that have public, government and scientists or adopt a different attitude. At this moment, he points out there is too much emphasis on healing in gerontology from diseases associated with old age, and must be dealt with according to him, the causes of aging itself. de Grey talks about a pro-aging trance: we tend to see decay and death as inevitable phenomena. To live we love ourselves that death is not only inevitable but also desirable with this idea. This helps us to cope with the thought of death, but also ensures that we do not take action to fix aging once and for all.
De Grey argues that we can prevent geriatric diseases through molecular and cellular damage that restore the body with age rising time. If the damage is too great, it leads to aging and eventually death. According to de Grey scientists able to understand these mechanisms through basic research and develop methods to repair the damage before age ailments occur. It's a matter of time before old age can be eradicated in this way. Death has nothing to do with biological age.
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This handsome Greek youth is worshiped by Eos, goddess of the Dawn. She asks Zeus to grant her mortal lover to eternal life. Unfortunately, they also forget to ask for eternal youth and health; Tithonos is so old that he no longer can move and shrivels to a grasshopper. The Tithonos fallacy is scientific research in its current state, says De Grey. Scientists focus to much on combating age-related diseases. According to de Grey, the underlying problem is neglected, the disease of age itself.Bas Heijne is a Dutch writer and interviewer. He studied English language and literature, has published numerous books and is well-known for his opinionated essays and columns in newspaper NRC Handelsblad. For the tv series De Volmaakte Mens, Heijne went on a personal quest to discover what defines 'being human' in our increasingly technological society. He interviewed philosophers, technologists and scientists around the world, in search of the future of the human species.
This interview is an excerpt from the Dutch science programme De Volmaakte Mens (“The Perfect Human Being”), episode 2 'Challenging Death'. The six-part science series De Volmaakte Mens was broadcast on Dutch television in Spring 2015.
Friday, June 27, 2014
Anti-Aging
| Stephen Sackur of BBC News recently interviewed Aubrey de Grey asking difficult questions about his research and his personal mindset. |
Gerontologist and founder of the SENS Research Foundation Dr. Aubrey de Grey recently sat down with Stephen Sackur on the BBC program HARDtalk to discuss his work on combating aging. The interview follows the pair's other recent interview at the St. Gallen Symposium last month.
In both cases Sackur presents his questions in the form that de Grey is very much on the fringe and that his research may even be considered "inspiring, daft or downright dangerous."
"I've always assumed that aging is natural; that it is part of the evolutionary process," says Sackur leading off.
"You're absolutely wrong," counters de Grey. "The word 'natural' must not be misused. All of technology is about humanity manipulating nature for it's own ends. Whether its fire or the wheel, or antibiotics or anything, what we are doing is taking what is natural and saying 'That's not good enough.'"
De Grey also clarifies the notion that aging and death are mechanisms of evolution. Most animals in nature, do not reach the stage where aging takes place because they either are eaten or they die of starvation or other causes.
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De Grey clarifies this as well. He advises that Sackur check the dates of these criticisms, as their instinctual claims have been countered by the SENS Foundation's work at educating those critics, and making the work seem overall "less crazy sounding."
The discussion also touches on some of the potential future considerations with a population that has overcome aging.
When Sackur presses de Grey on what such a future would mean for our children, and how will they make sense of the world de Grey responds, "That's like saying does human society make sense now, when it is so different than how things were 300 years ago when 40% of the population died before the age of one. It is a very different world now, but it still makes sense."
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Monday, February 24, 2014
Regenerative Medicine
| At the SENS Foundation Conference, Malcolm Maden from the University of Florida detailed how the organism can regrow limbs and organs, and what implications this may have for regenerative medicine. |
The most amazing organ regenerative ability is displayed by salamanders and other Urodele amphibians such as axolotls which can regenerate brains, spinal cord, limbs, tails, heart, lower jaw and other structures.
At the SENS Foundation Conference (SENS6), Malcolm Maden from the University of Florida detailed how the organism can regrow limbs and organs, and what implications this may have for regenerative medicine.
There are many reasons for studying regenerative mechanisms in these organisms and one of the most intriguing may be the relation between regeneration and aging.
How old are the cells of a regenerated organ -- the same as the host animal or is age reset in a dedifferentiated multipotent stem cell? Nothing is known about this phenomenon apart from the demonstration that regenerative ability does not decline with age in Urodeles -- the quality of the last regenerate is as good as the first.
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According to Maden, his team has had some success at inducing regeneration in mammals by extrapolating from our understanding of axolotl regeneration, in particular concerning one developmental signaling molecule, retinoic acid.
As Maden shows, this molecule is critically required for limb development, limb regeneration, heart regeneration and when administered in excess induces the duplication of limbs. His research is revealing the mechanism of action and targets in the nucleus are gradually and how it interacts with other developmental signaling pathways.
can induce a regenerative response in mammalian organs which cannot normally regenerate such as the lung and the spinal cord."We have therefore referred to this molecule as a regeneration-inducing molecule. Our recent studies have also revealed the role of retinoic acid in neurodegenerative diseases such as Alzheimer's disease and in a mouse model of this disease it has the remarkable effect of reducing plaque load and the levels of the toxic Ab peptide in the brain," he says. "Retinoic acid may thus really have life-extending properties and we anticipate that further research may also give us insights into the ageing process itself."
SOURCE SENS Foundation
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Friday, November 15, 2013
Aging
| Aubrey de Grey believes we can, and should, find medical interventions to repair the effects of aging. In this talk, he explains his research program and shares some recent discoveries. |
Biomedical Gerontologist Aubrey de Grey believes we can, and should, find medical interventions to repair the effects of aging. In this talk, he explains his research program and shares some recent discoveries.
De Grey is the Chief Science Officer of SENS Research Foundation, a California-based 501(c)(3) charity dedicated to combating the aging process.
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His plan for such repair, termed Strategies for Engineered Negligible Senescence (SENS), breaks aging down into seven major classes of damage and identifies detailed approaches to addressing each one. He is a Fellow of both the Gerontological Society of America and the American Aging Association, and sits on the editorial and scientific advisory boards of numerous journals and organization.
SOURCE TEDx Talks
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Wednesday, October 16, 2013
Anti-Aging
| Recently Alcor Cryonics shared a talk given by Aubrey de Grey at last year's Alcor 40th Anniversary Conference featuring work done by the SENS Foundation to fight aging. |
At last year's 40th Anniversary Conference at Alcor Cryonics Aubrey de Grey discussed work done by the SENS Foundation to fight aging. He also talked about other research that may have a significant effect on aging.
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Dr. de Grey is a biomedical gerontologist based in Cambridge, UK and Mountain View, California, and is the Chief Science Officer of SENS Foundation, a California-based charity dedicated to combating the aging process.
According to de Grey, there are seven types of damage that need to be addressed by regenerative medicine in order to solve the aging problem:
So far de Grey is positive about the work at the SENS Foundation, "We have very good reason to believe that we are on a good track and that we have demonstrated our robustness."
SOURCE Alcor Cryonics
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Thursday, January 3, 2013
| In a recent interview with the French site JOL Press, gerontologist Aubrey de Grey suggested that his SENS Foundation was very close to announcing a major breakthrough in a rejuvenation biotechnology for the prevention and mitigation of cardiovascular disease. |
SENS is an acronym for "Strategies for Engineered Negligible Senescence". The work at the SENS Foundation is described as an integrated set of medical techniques designed to restore youthful molecular and cellular structure to aged tissues and organs. Essentially, this involves the application of regenerative medicine to the problem of age-related sickness and disease.
Regenerative medicine is usually encompasses a few specific technologies such as stem cell therapy and tissue engineering, whereas SENS incorporates a variety of other techniques to remove or obviate the accumulating damage of aging. This broadly defined regenerative medicine - which includes the repair of living cells and extra-cellular material in situ - applied to damage of aging, is what the organization refers to as rejuvenation biotechnologies.
Now, in a recent interview with de Grey at the French site, JOL Press, the gerontologist commented:
He continues, "We are continuing our experiments. If all goes as we hope, we expect significant gains in the rats of 8 to 10 years, then apply to humans in 20 or 40 years."
Although mortality rates have declined in higher-income countries over the last two decades cardiovascular diseases remain the biggest cause of deaths worldwide. Moreover, cardiovascular deaths and disease are on the rise at a fast rate in low- and middle-income countries.
As soon as more information becomes available on SENS's work, we will let you know.
SOURCE JOL Press
We just received this note from the SENS Foundation:
Dear 33rd Square Team,
I just wanted to let you know that the French interview that served as the basis for your article on SENS and heart disease from January 3 (http://www.33rdsquare.com/2013/01/sens-foundation-close-to-breakthrough.html) appears to contain something of a mistranslation. When Dr. de Grey was discussing LysoSENS, he was referring to a recent publication generated by Rice University, which is discussed briefly on our website at http://sens.org/node/2990. These are very exciting results, and we’re looking forward to funding more of Dr. Mathieu’s work to generate further advances; any treatment that may come from this research is still years away, though. The science is progressing nicely, but there is no imminent breakthrough to be announced shortly.
Daniel Kimbel
Media Relations
SENS Foundation
Now, in a recent interview with de Grey at the French site, JOL Press, the gerontologist commented:
"One of our projects which we hope to make public soon, is a revolutionary advance to insert a gene in our patients from a bacteria and prevent them from dying from cardiovascular disease - the No. 1 cause of death today."
He continues, "We are continuing our experiments. If all goes as we hope, we expect significant gains in the rats of 8 to 10 years, then apply to humans in 20 or 40 years."
Although mortality rates have declined in higher-income countries over the last two decades cardiovascular diseases remain the biggest cause of deaths worldwide. Moreover, cardiovascular deaths and disease are on the rise at a fast rate in low- and middle-income countries.
SOURCE JOL Press
*NOTICE- January 7, 2013
We just received this note from the SENS Foundation:
Dear 33rd Square Team,
I just wanted to let you know that the French interview that served as the basis for your article on SENS and heart disease from January 3 (http://www.33rdsquare.com/2013/01/sens-foundation-close-to-breakthrough.html) appears to contain something of a mistranslation. When Dr. de Grey was discussing LysoSENS, he was referring to a recent publication generated by Rice University, which is discussed briefly on our website at http://sens.org/node/2990. These are very exciting results, and we’re looking forward to funding more of Dr. Mathieu’s work to generate further advances; any treatment that may come from this research is still years away, though. The science is progressing nicely, but there is no imminent breakthrough to be announced shortly.
Daniel Kimbel
Media Relations
SENS Foundation
We appreciate this feedback from the SENS Foundation and remain firm supporters of their important work.
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